What causes platelet clumping in cats?
It was reported that the quality of blood collection is the major cause of PLT aggregates in feline EDTA blood [1, 12, 13]. Small vessels and difficulties in handling of the feline often result in a difficult blood collection.
What disease causes platelet clumping?
Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. Thrombocytopenia might occur as a result of a bone marrow disorder such as leukemia or an immune system problem. Or it can be a side effect of taking certain medications. It affects both children and adults.
What does it mean if platelets are clumping?
Platelet clumping occurs when the blood platelets responsible for coagulation stick to one another to form clusters. The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets.
How do you fix platelet clumping?
Causes of platelet clumping include platelet activation (due to traumatic venipuncture) and EDTA-dependent antibodies that react with platelet glycoprotein IIb/IIIa. In the latter case, the clumping can be corrected by using blood collection tubes containing an alternative anticoagulant, such as sodium citrate
What does platelet clumping mean in cats?
Platelet clumping is a common problem in cats. Platelet clumps result in platelet counts (manual and machine generated) being falsely decreased, and severe clumping may result in the platelet count being falsely reported as thrombocytopenia (pseudothrombocytopenia).
What is the most common reason for platelet clumps?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
What is the most common cause of low platelet count in cats?
Causes of platelet clumping include platelet activation (due to traumatic venipuncture) and EDTA-dependent antibodies that react with platelet glycoprotein IIb/IIIa. In the latter case, the clumping can be corrected by using blood collection tubes containing an alternative anticoagulant, such as sodium citrate
What causes platelet clumping?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
What happens when platelets clump?
Platelet clumping occurs when the blood platelets responsible for coagulation stick to one another to form clusters. The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets
What medications can cause platelet clumping?
Causes
- Furosemide.
- Gold, used to treat arthritis.
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Penicillin.
- Quinidine.
- Quinine.
- Ranitidine.
- Sulfonamides.
What disorders are associated with platelets?
The most common types are:
- Bernard Soulier disease.
- Glanzmann’s thrombasthenia.
- Hermansky Pudlak syndrome.
- Jacobsen syndrome.
- Lowe syndrome.
- Platelet release and storage pool defects.
- Thrombocytopenia with absent radius (TAR) syndrome.
- Thrombotic thrombocytopenic purpura (TTP)
18-Dec-2018
How common is platelet clumping?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
Can platelet clumping cause blood clots?
Results: Thrombocytopenic patients with viral infection had a higher frequency of platelet clumping than those with other diseases, which was statistically significant (13.8% vs. 6.5%, respectively: P 0.003).
What is the clumping of platelets called?
When this occurs, the platelets aggregate or clump together, resulting in platelet usage and a fall in the patient’s platelet count (thrombocytopenia). Damage to the blood vessel wall and platelet clumping associated with heparin-induced thrombocytopenia can lead to blood clots despite the presence of heparin
Is platelet clumping serious?
The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets.
How do you deal with platelet clumping?
Many labs will have an alternate tube drawn or use another method to help resolve the clumping. Less commonly used tubes are CTAD (trisodium citrate, theophylline, adenosine, dipyridamole) and heparin. CTAD acts directly on platelets and inhibits platelet factor 4 thus minimizing platelet activation.
Why would platelets be clumped?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
Why would a cat’s platelets be low?
Decreased production of platelets may be caused by drugs, toxins, or disorders of the bone marrow. Platelets can also be inappropriately destroyed in the blood by the cat’s own immune system.
What infections cause low platelets in cats?
infectious diseases such as feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), feline infectious peritonitis (FIP), panleukopenia virus, cytauxzoonosis, salmonellosis, ehrlichiosis, toxoplasmosis, and heartworm disease. immune-mediated diseases such as immune-mediated thrombocytopenia.
What deficiency causes low platelets?
Vitamin B-12 helps keep your blood cells healthy. A deficiency of B-12 has been associated with low platelet counts. The best sources of vitamin B-12 tend to be animal-based foods, such as: beef liver.
What is the most common cause of low platelet count?
One of the most common causes of low platelets is a condition called immune thrombocytopenia (ITP). You may hear it called by its old name, idiopathic thrombocytopenic purpura.
What does it mean if your platelets are clumping?
Platelet clumping occurs when the blood platelets responsible for coagulation stick to one another to form clusters. The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets.
Is platelet clumping normal?
Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. Thrombocytopenia might occur as a result of a bone marrow disorder such as leukemia or an immune system problem. Or it can be a side effect of taking certain medications. It affects both children and adults.
Why would platelets appear clumped?
Platelet clumping is most commonly caused by pre-analytic errors such as improper or delayed sample mixing, clotted sample, over-filled or underfilled tubes, and time delay between sample collection and testing. It can also be an ex vivo phenomenon due to EDTA-dependent antibodies.
What happens if platelets stick together?
Platelets stick together, helping blood to form a clot that stops bleeding when you damage a blood vessel, such as when you cut yourself. Thrombocytosis occurs when your body produces too many platelets.
